What are the leading causes of kidney failure?
At present, diabetes is the leading cause of chronic kidney disease, especially ESRD or kidney failure. If high blood sugar is uncontrolled effectively, it can damage blood vessels all over the body as well as kidneys. Within kidneys, tiny blood vessels are responsible for filtering out wastes. Diabetes can disturb this system, so as to cause kidney damage.
2. High blood pressure
Hypertension, secondary to diabetes, is another leading cause of kidney failure. Hypertension can cause the increase of pressure within blood vessels that leads to protein leaking from blood into urine. Once protein leaks out, it can cause damage to kidney filtering system. Finally, this results in vicious circle. Long-term damage causes irreversible kidney damage so that kidney fails in advance.
3. Disorders of immune system
IgA Nephropathy, FSGS, Lupus Nephritis and many other types of kidney disease are all a result of immune disorders. Most often, the prognosis of these kidney diseases are not as good as we expect. If uncontrolled effectively in the early stage, they will eventually develop to kidney failure.
4. Inherited problems
Polycystic Kidney Disease is another cause of kidney failure, and it is an inherited kidney disorder. Generally, PKD progresses slowly, and nearly 50% of PKD patients have kidney failure at age 60. In that situation, patients have to live with dialysis or kidney transplant.